Genes of SARS-CoV-2 and emerging variants
نویسندگان
چکیده
The pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is distinctly different from outbreaks other coronaviruses: SARS-CoV and Middle East coronavirus (MERS-CoV). differences in the rapid transmission severity of human coronaviruses are due to genetic composition virus. SARS-CoV-2 contains genes encoding non-structural proteins (NSPs), structural proteins, accessory proteins. NSPs mainly involved replication virus within host inhibition defence system. Structural viral entry attachment cells, preservation core virion elicit majority immune response. functions largely unknown. Most focus has been given especially spike protein as strongest vaccine candidate. However, recent emergence variants their ability rapidly transmit escape neutralisation vaccine-induced antibodies threatened global community. Meanwhile, studies reveal importance pathogenesis. Hence, proper understanding all unknown crucial devise alternate antiviral strategies.
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ژورنال
عنوان ژورنال: Microbiology Australia
سال: 2021
ISSN: ['1324-4272', '2201-9189']
DOI: https://doi.org/10.1071/ma21004